A STAT3-based gene signature stratifies glioma patients for targeted therapy

Melanie Si Yan Tan; Edwin Sandanaraj; Yuk Kien Chong; See Wee Lim; Lynnette Wei Hsien Koh; Wai Hoe Ng; Nguan Soon Tan; Patrick Tan; Beng Ti Ang; Carol Tang

doi:10.1038/s41467-019-11614-x

Nature Communications (Aug 2019)

A STAT3-based gene signature stratifies glioma patients for targeted therapy

Melanie Si Yan Tan,
Edwin Sandanaraj,
Yuk Kien Chong,
See Wee Lim,
Lynnette Wei Hsien Koh,
Wai Hoe Ng,
Nguan Soon Tan,
Patrick Tan,
Beng Ti Ang,
Carol Tang

Affiliations

Melanie Si Yan Tan: Neuro-Oncology Research Laboratory, Department of Research, National Neuroscience Institute
Edwin Sandanaraj: Neuro-Oncology Research Laboratory, Department of Research, National Neuroscience Institute
Yuk Kien Chong: Neuro-Oncology Research Laboratory, Department of Research, National Neuroscience Institute
See Wee Lim: Neuro-Oncology Research Laboratory, Department of Research, National Neuroscience Institute
Lynnette Wei Hsien Koh: Neuro-Oncology Research Laboratory, Department of Research, National Neuroscience Institute
Wai Hoe Ng: Department of Neurosurgery, National Neuroscience Institute
Nguan Soon Tan: School of Biological Sciences, Nanyang Technological University
Patrick Tan: Duke-National University of Singapore Medical School
Beng Ti Ang: Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR)
Carol Tang: Neuro-Oncology Research Laboratory, Department of Research, National Neuroscience Institute

DOI: https://doi.org/10.1038/s41467-019-11614-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

STAT3 activates distinct transcriptional programmes within cancer cells. In this study, the authors find that, in glioma, a STAT3-mediated expression signature can stratify patients for targeted precision therapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal