IKBA phosphorylation governs human sperm motility through ACC-mediated fatty acid beta-oxidation

Affiliations

Yanquan Li: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University
Youwei Hu: State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University
Zhengquan Wang: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University
Tingting Lu: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University
Yiting Yang: NPFPC Key Laboratory of Contraceptives and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies
Hua Diao: NPFPC Key Laboratory of Contraceptives and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies
Xiaoguo Zheng: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University
Chong Xie: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University
Ping Zhang: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University
Xuelian Zhang: State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University
Yuchuan Zhou: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University

Abstract

NF-κB inhibitor alpha (IKBA) signaling in mature sperm drives sperm motility and controls fatty acid b-oxidation metabolism.