Brain milieu induces early microglial maturation through the BAX-Notch axis

Fangying Zhao; Jiangyong He; Jun Tang; Nianfei Cui; Yanyan Shi; Zhifan Li; Shengnan Liu; Yazhou Wang; Ming Ma; Congjian Zhao; Lingfei Luo; Li Li

doi:10.1038/s41467-022-33836-2

Nature Communications (Oct 2022)

Brain milieu induces early microglial maturation through the BAX-Notch axis

Fangying Zhao,
Jiangyong He,
Jun Tang,
Nianfei Cui,
Yanyan Shi,
Zhifan Li,
Shengnan Liu,
Yazhou Wang,
Ming Ma,
Congjian Zhao,
Lingfei Luo,
Li Li

Affiliations

Fangying Zhao: Institute of Developmental Biology and Regenerative Medicine, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Southwest University
Jiangyong He: Institute of Developmental Biology and Regenerative Medicine, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Southwest University
Jun Tang: Institute of Developmental Biology and Regenerative Medicine, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Southwest University
Nianfei Cui: Institute of Developmental Biology and Regenerative Medicine, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Southwest University
Yanyan Shi: Institute of Developmental Biology and Regenerative Medicine, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Southwest University
Zhifan Li: Institute of Developmental Biology and Regenerative Medicine, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Southwest University
Shengnan Liu: Institute of Developmental Biology and Regenerative Medicine, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Southwest University
Yazhou Wang: Department of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University
Ming Ma: Institute of Developmental Biology and Regenerative Medicine, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Southwest University
Congjian Zhao: Chongqing Engineering Research Center of Medical Electronics and Information Technology, School of Bioinformatics, Chongqing University of Posts and Telecommunications
Lingfei Luo: Institute of Developmental Biology and Regenerative Medicine, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Southwest University
Li Li: Institute of Developmental Biology and Regenerative Medicine, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Southwest University

DOI: https://doi.org/10.1038/s41467-022-33836-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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The mechanisms by which the brain milieu confers microglial development are not clear. Here, the authors show that the BAX-CaMKII-CREB-Notch signaling axis triggered by the neuronal milieu plays a role in early microglia maturation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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