Limited Impact of Drone Transport of Blood on Platelet Activation

Abstract

The rapid transportation of blood samples and blood products using drones has high potential in the medical sector. However, before this can be implemented, sufficient evidence that drone transportation is not affecting clinical outcomes is needed. Currently, limited data on the stability of blood, and specifically on platelet activation, after transport using drones are available. Therefore, the impact of drone transportation on platelet activation parameters was analyzed. Blood was drawn from 20 healthy volunteers and lactate dehydrogenase (LDH), potassium, free hemoglobin, PFA-100 closure time, platelet factor 4 (PF4) plasma levels and platelet activation membrane markers were determined in blood that was transported by drone and compared to non-transported samples. In addition, a control group was included where blood samples were transported by car. Transport by both drone and car increased LDH and potassium levels, but the values mostly remained within the total allowable error. Both drone and car transportation impacted platelet activation, as indicated by a small increase in the baseline P-selectin expression and increased PF4 plasma levels. To our knowledge, this is the first study assessing the impact of drone transport on platelet activation. Transportation of blood tubes from healthy individuals using drones has only minimal impacts on blood stability and platelet activation parameters, and is comparable to blood transportation by car. Therefore, the effects observed as a result of drone transportation will likely not impact clinical decision making.

Keywords

• blood quality
• drone transport
• platelets
• platelet activation