Copper-mediated oxidative C−H/N−H activations with alkynes by removable hydrazides

Abstract

The efficient copper-mediated oxidative C–H alkynylation of benzhydrazides was accomplished with terminal alkynes. Thus, a heteroaromatic removable N-2-pyridylhydrazide allowed for domino C–H/N–H functionalization. The approach featured remarkable functional group compatibility and ample substrate scope. Thereby, highly functionalized aromatic and heteroaromatic isoindolin-1-ones were accessed with high efficacy with rate-limiting C–H cleavage.

Keywords

• benzhydrazides
• copper
• 3-methyleneisoindolin-1-one
• removable directing group