Antioxidant and radical scavenging activities of some norcantharidin and bridged perhydroisoindole derivatives

Abstract

A series of norcantharidin and bridged perhydroisoindole derivatives were evaluated for their antioxidant and radical scavenging activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2- picrylhydrazil (DPPH•) free radical scavenging, superoxide anion radical scavenging and metal chelating activities were used. Among 11 compounds tested, 7 compounds showed potent reducing power activity and 8 compounds showed potent superoxide anion radical scavenging activity. All the tested compounds exhibited potent free radical scavenging ability. The results showed that the synthesized compounds had effective antioxidant power.

Keywords

• norcantharidin
• bridged perhydroisoindole
• reducing power
• superoxide anion radical