Nature Communications (Mar 2021)

ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

  • Yusuke Shiromoto,
  • Masayuki Sakurai,
  • Moeko Minakuchi,
  • Kentaro Ariyoshi,
  • Kazuko Nishikura

DOI
https://doi.org/10.1038/s41467-021-21921-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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One type of RNA editing involves ADAR-mediated conversion of adenosine to inosine. Here the authors show that ADAR1 nuclear isoform p110 regulates R loop formation and genome stability at telomeres in cancer cells.