An In Vivo Assessment of the Effect of Hexane Extract from <i>Endlicheria paniculata</i> Branches and Its Main Compound, Methyldehydrodieugenol B, on Murine Sponge-Induced Inflammation
Bruno Antonio Ferreira,
Rafael Aparecido Carvalho Souza,
Francyelle Borges Rosa de Moura,
Tiara da Costa Silva,
Tais da Silva Adriano,
Eduardo de Faria Franca,
Raquel Maria Ferreira de Sousa,
Fernanda de Assis Araújo,
João Henrique Ghilardi Lago,
Alberto de Oliveira
Affiliations
Bruno Antonio Ferreira
Department of Physiological Sciences, Federal University of Uberlandia, Uberlandia 38408-100, Brazil
Rafael Aparecido Carvalho Souza
Institute of Chemistry, Federal University of Uberlandia, Uberlandia 38408-100, Brazil
Francyelle Borges Rosa de Moura
Department of Cell Biology, Histology and Embryology, Federal University of Uberlandia, Uberlandia 38408-100, Brazil
Tiara da Costa Silva
Institute of Chemistry, Federal University of Uberlandia, Uberlandia 38408-100, Brazil
Tais da Silva Adriano
Institute of Chemistry, Federal University of Uberlandia, Uberlandia 38408-100, Brazil
Eduardo de Faria Franca
Institute of Chemistry, Federal University of Uberlandia, Uberlandia 38408-100, Brazil
Raquel Maria Ferreira de Sousa
Institute of Chemistry, Federal University of Uberlandia, Uberlandia 38408-100, Brazil
Fernanda de Assis Araújo
Department of Physiological Sciences, Federal University of Uberlandia, Uberlandia 38408-100, Brazil
João Henrique Ghilardi Lago
Center for Natural and Human Sciences, Federal University of ABC, Santo Andre 09210-180, Brazil
Alberto de Oliveira
Institute of Chemistry, Federal University of Uberlandia, Uberlandia 38408-100, Brazil
The present study aims to explore the anti-inflammatory potential activity of the hexane extract from branches (HEB) of Endlicheria paniculata (Lauraceae) and its main compound, methyldehydrodieugenol B, in the inflammatory response induced by a murine implant sponge model. HPLC-ESI/MS analysis of HEB led to the identification of six chemically related neolignans, with methyldehydrodieugenol B as the main compound. An in silico analysis of the pharmacokinetic parameters of the identified compounds suggested moderate solubility but good absorption and biodistribution in vivo. Thus, the treatment of mice with HEB using in vivo assays indicated that HEB promoted pro-inflammatory, antiangiogenic, and antifibrogenic effects, whereas treatment with methyldehydrodieugenol B caused anti-inflammatory, antifibrogenic, and antiangiogenic effects. The obtained results shown the therapeutic potential of HEB and methyldehydrodieugenol B in the treatment of pathologies associated with inflammation and angiogenesis, including chronic wounds.
