Nature Communications (Apr 2019)
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
- Robert Fledrich,
- Dagmar Akkermann,
- Vlad Schütza,
- Tamer A. Abdelaal,
- Doris Hermes,
- Erik Schäffner,
- M. Clara Soto-Bernardini,
- Tilmann Götze,
- Axel Klink,
- Kathrin Kusch,
- Martin Krueger,
- Theresa Kungl,
- Clara Frydrychowicz,
- Wiebke Möbius,
- Wolfgang Brück,
- Wolf C. Mueller,
- Ingo Bechmann,
- Michael W. Sereda,
- Markus H. Schwab,
- Klaus-Armin Nave,
- Ruth M. Stassart
Affiliations
- Robert Fledrich
- Institute of Anatomy, University of Leipzig
- Dagmar Akkermann
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Vlad Schütza
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Tamer A. Abdelaal
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Doris Hermes
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Erik Schäffner
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- M. Clara Soto-Bernardini
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Tilmann Götze
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Axel Klink
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Kathrin Kusch
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Martin Krueger
- Institute of Anatomy, University of Leipzig
- Theresa Kungl
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Clara Frydrychowicz
- Department of Neuropathology, University Hospital Leipzig
- Wiebke Möbius
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Wolfgang Brück
- Institute of Neuropathology, University Medical Center Göttingen
- Wolf C. Mueller
- Department of Neuropathology, University Hospital Leipzig
- Ingo Bechmann
- Institute of Anatomy, University of Leipzig
- Michael W. Sereda
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Markus H. Schwab
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Klaus-Armin Nave
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- Ruth M. Stassart
- Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine
- DOI
- https://doi.org/10.1038/s41467-019-09385-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Onion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.
