Nature Communications (Jul 2017)

Physical limits to biomechanical sensing in disordered fibre networks

  • Farzan Beroz,
  • Louise M. Jawerth,
  • Stefan Münster,
  • David A. Weitz,
  • Chase P. Broedersz,
  • Ned S. Wingreen

DOI
https://doi.org/10.1038/ncomms16096
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Cells in the connective tissue are surrounded by a heterogeneous network of biopolymers. Here, the authors investigate how such heterogeneity affects cellular mechanosensing by simulating the deformation response of experimental and modelled biopolymer networks to locally applied forces.