Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy

Ellen Verhoef; Jakob Grove; Chin Yang Shapland; Ditte Demontis; Stephen Burgess; Dheeraj Rai; Anders D. Børglum; Beate St Pourcain

doi:10.1038/s41467-021-26755-1

Nature Communications (Nov 2021)

Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy

Ellen Verhoef,
Jakob Grove,
Chin Yang Shapland,
Ditte Demontis,
Stephen Burgess,
Dheeraj Rai,
Anders D. Børglum,
Beate St Pourcain

Affiliations

Ellen Verhoef: Language and Genetics Department, Max Planck Institute for Psycholinguistics
Jakob Grove: The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
Chin Yang Shapland: MRC Integrative Epidemiology Unit, University of Bristol
Ditte Demontis: The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
Stephen Burgess: MRC Biostatistics Unit, University of Cambridge
Dheeraj Rai: Centre for Academic Mental Health, Bristol Medical School, University of Bristol
Anders D. Børglum: The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
Beate St Pourcain: Language and Genetics Department, Max Planck Institute for Psycholinguistics

DOI: https://doi.org/10.1038/s41467-021-26755-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder are co-occurring neurodevelopmental conditions displaying strong, discordant polygenic associations with educational attainment. Here, the authors study genetic mechanisms underlying genome-wide correlation patterns across these traits.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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