Nature Communications (May 2018)
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
- Amlan Biswas,
- Dror S. Shouval,
- Alexandra Griffith,
- Jeremy A. Goettel,
- Michael Field,
- Yu Hui Kang,
- Liza Konnikova,
- Erin Janssen,
- Naresh Singh Redhu,
- Adrian J. Thrasher,
- Talal Chatila,
- Vijay K. Kuchroo,
- Raif S Geha,
- Luigi D. Notarangelo,
- Sung-Yun Pai,
- Bruce H. Horwitz,
- Scott B. Snapper
Affiliations
- Amlan Biswas
- Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital
- Dror S. Shouval
- Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital
- Alexandra Griffith
- Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital
- Jeremy A. Goettel
- Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital
- Michael Field
- Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital
- Yu Hui Kang
- Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital
- Liza Konnikova
- Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital
- Erin Janssen
- Department of Pediatrics, Harvard Medical School
- Naresh Singh Redhu
- Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital
- Adrian J. Thrasher
- Great Ormond Street Hospital NHS Trust, London and Institute of Child Health, University College London
- Talal Chatila
- Department of Pediatrics, Harvard Medical School
- Vijay K. Kuchroo
- Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital
- Raif S Geha
- Department of Pediatrics, Harvard Medical School
- Luigi D. Notarangelo
- Clinical Immunology and Microbiology, NIAID, National Institutes of Health
- Sung-Yun Pai
- Division of Hematology-Oncology, Boston Children’s Hospital Boston
- Bruce H. Horwitz
- Department of Pediatrics, Harvard Medical School
- Scott B. Snapper
- Division of Gastroenterology, Hepatology and Nutrition, Boston Children’s Hospital
- DOI
- https://doi.org/10.1038/s41467-018-03670-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Deficiency in Wiskott-Aldrich syndrome protein (WASP) has been associated with autoimmune colitis, but the underlying mechanism is still unclear. Here the authors show that WASP deficiency is associated with defective WASP/DOCK8 complex formation, altered IL-10 signalling, and impaired anti-inflammatory macrophage functions.
