Nature Communications (May 2018)

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

  • Amlan Biswas,
  • Dror S. Shouval,
  • Alexandra Griffith,
  • Jeremy A. Goettel,
  • Michael Field,
  • Yu Hui Kang,
  • Liza Konnikova,
  • Erin Janssen,
  • Naresh Singh Redhu,
  • Adrian J. Thrasher,
  • Talal Chatila,
  • Vijay K. Kuchroo,
  • Raif S Geha,
  • Luigi D. Notarangelo,
  • Sung-Yun Pai,
  • Bruce H. Horwitz,
  • Scott B. Snapper

DOI
https://doi.org/10.1038/s41467-018-03670-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Deficiency in Wiskott-Aldrich syndrome protein (WASP) has been associated with autoimmune colitis, but the underlying mechanism is still unclear. Here the authors show that WASP deficiency is associated with defective WASP/DOCK8 complex formation, altered IL-10 signalling, and impaired anti-inflammatory macrophage functions.