Frontiers in Endocrinology (Feb 2023)
Individual and combined associations of body mass index and waist circumference with components of metabolic syndrome among multiethnic middle-aged and older adults: A cross-sectional study
Abstract
ObjectivesBody mass index (BMI) and waist circumference (WC) are closely associated with metabolic syndrome and its components. Hence, a combination of these two obesity markers may be more predictive. In this study, we aimed to investigate the individual and combined associations of BMI and WC with selected components of metabolic syndrome and explored whether age, sex and ethnicity affected the aforementioned associations.MethodsA total of 6,298 middle-aged and older adults were included. Based on BMI and WC, the participants were divided into 4 groups: comorbid obesity (BMI ≥ 28 kg/m2 and WC< 85/90 cm for women/men), abdominal obesity alone (BMI< 28 kg/m2 and WC≥ 85/90 cm for women/men), general obesity alone (BMI ≥ 28 kg/m2 and WC< 85/90 cm for women/men) and nonobesity subgroups (BMI< 28 kg/m2 and WC< 85/90 cm for women/men). Selected components of metabolic syndrome were evaluated using the criteria recommended by the Chinese Diabetes Society. Poisson regression models with robust variance were used to evaluate the associations of obesity groups with selected components of metabolic syndrome. An interaction test was conducted to explore whether age, sex and ethnicity affect the aforementioned associations.ResultsCompared with participants in the reference group (comorbid obesity), participants in the other 3 groups showed a decreased prevalence of fasting hyperglycemia (PR=0.83, 95% CI=0.73–0.94 for abdominal obesity alone, PR=0.60, 95% CI=0.38–0.96 for general obesity alone and PR=0.46, 95% CI=0.40–0.53 for nonobesity), hypertension (PR=0.86, 95% CI=0.82–0.90 for abdominal obesity alone, PR=0.80, 95% CI=0.65–0.97 for general obesity alone and PR=0.69, 95% CI = 0.66–0.73 for nonobesity) and hypertriglyceridemia (PR=0.88, 95% CI=0.82–0.95 for abdominal obesity alone, PR=0.62, 95% CI=0.47–0.81 for general obesity alone and PR=0.53, 95% CI=0.49–0.57 for nonobesity). However, participants in the abdominal obesity alone and nonobesity groups showed a decreased prevalence of low HDL-C levels while participants in the general obesity alone group did not (PR=0.65, 95% CI=0.41–1.03, p>0.05). In addition, the aforementioned associations were not affected by age, sex or ethnicity (all p for interactions>0.05).ConclusionsComorbid obesity is superior to general and abdominal obesity in identifying individuals at high risk of developing metabolic syndrome in middle-aged and older adults. Great importance should be attached to the combined effect of BMI and WC on the prevention and management of metabolic syndrome.
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