Gut Pathogens (Dec 2009)

Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of <it>Listeria monocytogenes</it>

  • Van de Velde Sébastien,
  • Carryn Stéphane,
  • Van Bambeke Françoise,
  • Hill Colin,
  • Tulkens Paul M,
  • Sleator Roy D

DOI
https://doi.org/10.1186/1757-4749-1-23
Journal volume & issue
Vol. 1, no. 1
p. 23

Abstract

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Abstract While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.