Фармакокинетика и Фармакодинамика (Jul 2017)

Pharmacokinetics of dipeptide anxiolytic GB-115 after oral administration in different animals species and humans

  • S. Yu. Raskin,
  • G. B. Kolyvanov,
  • A. A. Litvin,
  • P. O. Bochkov,
  • R. V. Shevchenko,
  • V. V. Smirnov,
  • O. G. Grybakina,
  • A. A. Novitskyi,
  • V. P. Zherdev,
  • L. G. Kolik,
  • T. A. Gudasheva,
  • N. Yu. Ivashkina

Journal volume & issue
Vol. 0, no. 3
pp. 20 – 25

Abstract

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Results of pharmacokinetic study of a new dipeptide anxiolytic GB-115 in rats, rabbits and volunteers were presented. After oral drug administration significant differences were found. For example, a dose-independent parameter - the elimination rate constant was decreased: rat < human < rabbit. By contrast the half-life of GB-115 was increased: rat

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