Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

Kerry L. Hilligan; Shiau-Choot Tang; Evelyn J. Hyde; Elsa Roussel; Johannes U. Mayer; Jianping Yang; Kirsty A. Wakelin; Alfonso J. Schmidt; Lisa M. Connor; Alan Sher; Andrew S. MacDonald; Franca Ronchese

doi:10.1038/s41467-020-19463-9

Nature Communications (Nov 2020)

Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

Kerry L. Hilligan,
Shiau-Choot Tang,
Evelyn J. Hyde,
Elsa Roussel,
Johannes U. Mayer,
Jianping Yang,
Kirsty A. Wakelin,
Alfonso J. Schmidt,
Lisa M. Connor,
Alan Sher,
Andrew S. MacDonald,
Franca Ronchese

Affiliations

Kerry L. Hilligan: Malaghan Institute of Medical Research
Shiau-Choot Tang: Malaghan Institute of Medical Research
Evelyn J. Hyde: Malaghan Institute of Medical Research
Elsa Roussel: Malaghan Institute of Medical Research
Johannes U. Mayer: Malaghan Institute of Medical Research
Jianping Yang: Malaghan Institute of Medical Research
Kirsty A. Wakelin: Malaghan Institute of Medical Research
Alfonso J. Schmidt: Malaghan Institute of Medical Research
Lisa M. Connor: Malaghan Institute of Medical Research
Alan Sher: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Andrew S. MacDonald: Lydia Becker Institute of Immunology and Inflammation, Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre
Franca Ronchese: Malaghan Institute of Medical Research

DOI: https://doi.org/10.1038/s41467-020-19463-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Antigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and monocytes in the specific induction of Th1, Th2 or Th17 responses following skin inoculation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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