Synthesis of New <i>bis</i> 1- and 5-Substituted 1<i>H</i>-Tetrazoles via Huisgen-Type 1,3-Dipolar Cycloadditions

Abstract

The synthesis and characterization of one symmetrical bis-1-substituted-1H-tetrazole (69%) via a Huisgen-type 1,3-dipolar cycloaddition, as well as, one symmetrical aza-linked bis-5-substituted-1H-tetrazole (57%) via a classic Huisgen 1,3-dipolar cycloaddition followed by a reductive aza-coupling under greener reaction conditions are described. The main reason behind these tetrazole-based ligands is to construct novel Metal-Organic Framework (MOF) architectures to evaluate their CO2 capture properties under relative humidity conditions. It is worthy to note that both herein reported products have not been synthesized nor isolated, anywhere. Besides, the synthesis of new ligands to fabricate novel MOFs with potential application in environmental remediation has become a highly valued field of opportunity for synthetic chemists and materials engineers.

Keywords

• Symmetrical bis-tetrazole-based ligands
• Huisgen 1,3-dipolar cycloadditions
• MOFs chemistry
• CO2 capture properties