Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters

Shufeng Liu; Charles B. Stauft; Prabhuanand Selvaraj; Prabha Chandrasekaran; Felice D’Agnillo; Chao-Kai Chou; Wells W. Wu; Christopher Z. Lien; Clement A. Meseda; Cyntia L. Pedro; Matthew F. Starost; Jerry P. Weir; Tony T. Wang

doi:10.1038/s41467-022-34571-4

Nature Communications (Nov 2022)

Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters

Shufeng Liu,
Charles B. Stauft,
Prabhuanand Selvaraj,
Prabha Chandrasekaran,
Felice D’Agnillo,
Chao-Kai Chou,
Wells W. Wu,
Christopher Z. Lien,
Clement A. Meseda,
Cyntia L. Pedro,
Matthew F. Starost,
Jerry P. Weir,
Tony T. Wang

Affiliations

Shufeng Liu: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration
Charles B. Stauft: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration
Prabhuanand Selvaraj: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration
Prabha Chandrasekaran: Laboratory of Clinical Investigation, National Institutes of Aging, National Institutes of Health
Felice D’Agnillo: Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration
Chao-Kai Chou: Facility for Biotechnology Resources, Center for Biologics Evaluation and Research, Food and Drug Administration
Wells W. Wu: Facility for Biotechnology Resources, Center for Biologics Evaluation and Research, Food and Drug Administration
Christopher Z. Lien: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration
Clement A. Meseda: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration
Cyntia L. Pedro: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration
Matthew F. Starost: Division of Veterinary Resources, Diagnostic and Research Services Branch, National Institutes of Health
Jerry P. Weir: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration
Tony T. Wang: Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration

DOI: https://doi.org/10.1038/s41467-022-34571-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Examples of effective live attenuated viral vaccines include the measles, mumps and rubella vaccine, as well as the chickenpox vaccine. In this work, the authors engineer a live attenuated SARS-CoV-2 virus that demonstrates attenuation in numerous in vivo models, and protection in hamsters upon challenge.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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