Nature Communications (May 2020)
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
- Jung-Min Kim,
- Yeon-Suk Yang,
- Kwang Hwan Park,
- Xianpeng Ge,
- Ren Xu,
- Na Li,
- Minkyung Song,
- Hyunho Chun,
- Seoyeon Bok,
- Julia F. Charles,
- Odile Filhol-Cochet,
- Brigitte Boldyreff,
- Teresa Dinter,
- Paul B. Yu,
- Ning Kon,
- Wei Gu,
- Takeshi Takarada,
- Matthew B. Greenblatt,
- Jae-Hyuck Shim
Affiliations
- Jung-Min Kim
- Department of Medicine, University of Massachusetts Medical School
- Yeon-Suk Yang
- Department of Medicine, University of Massachusetts Medical School
- Kwang Hwan Park
- Department of Orthopaedic Surgery, Yonsei University College of Medicine
- Xianpeng Ge
- Department of Medicine, University of Massachusetts Medical School
- Ren Xu
- State Key Laboratory of Cellular Stress Biology, Xiamen University
- Na Li
- State Key Laboratory of Cellular Stress Biology, Xiamen University
- Minkyung Song
- Department of integrative biotechnology, Sungkyunkwan University
- Hyunho Chun
- Department of Mathematical Sciences, Korea Advanced Institute of Science and Technology
- Seoyeon Bok
- Department of Pathology and Laboratory Medicine, Weill Cornell Medical College
- Julia F. Charles
- Department of Orthopedics and Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Odile Filhol-Cochet
- INSERM U1036, pour le Vivant/Biologie du Cancer et de l’Infection, Commissariat à l’Énergie Atomique et aux Énerigies Alternatives Grenoble
- Brigitte Boldyreff
- KinaseDetect ApS
- Teresa Dinter
- Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Paul B. Yu
- Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Ning Kon
- Institute of Cancer Genetics, College of Physicians and Surgeons of Columbia University
- Wei Gu
- Institute of Cancer Genetics, College of Physicians and Surgeons of Columbia University
- Takeshi Takarada
- Department of Regenerative Science, Okayama University Graduate School of Medicine
- Matthew B. Greenblatt
- Department of Pathology and Laboratory Medicine, Weill Cornell Medical College
- Jae-Hyuck Shim
- Department of Medicine, University of Massachusetts Medical School
- DOI
- https://doi.org/10.1038/s41467-020-16038-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein thereby regulating the commitment of SSCs to osteoprogenitors as well as their subsequent maturation, and that inhibition of this pathway can block heterotopic ossification.
