Cancer Control (Nov 2020)

Gastric Signet Ring Cell Carcinoma: A Comparative Analysis of Clinicopathologic Features

  • Boubacar Efared MD,
  • Mohamed Kadi MD,
  • Laila Tahiri MD,
  • Nada Lahmidani MD,
  • Karim Ibn Majdoub Hassani MD,
  • Hicham El Bouhaddouti MD,
  • Zineb Benbrahim MD,
  • Ibrahimi Sidi Adil MD,
  • Laila Chbani MD

DOI
https://doi.org/10.1177/1073274820976596
Journal volume & issue
Vol. 27

Abstract

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Signet ring cell carcinoma (SRC) is a distinct histological subtype of gastric carcinoma. Our aim is to investigate differential characteristics between gastric SRC and other non SRC carcinomas (nSRC). It was a retrospective study including 183 patients diagnosed with gastric carcinoma over a period of 5 years at our pathology department. We performed statistical comparison of clinicopathological features between patients with SRC and those with nSRC. 127 patients (69.4%) had nSRC, 56 had SRC (30.6%), the mean age was 56.67 ± 14.03 years. Patients with SRC were younger than those with nSRC (mean age of 49.66 versus 59.76, P = 0.030). Patients with SRC tend to have more diffuse tumors in the stomach ( P = 0.005), with flat macroscopic appearance ( P = 0.001). Patients with SRC present more often with pT3 tumors ( P 0.05). The median survival time was 42.82 ± 1.70 months. Patients with nSRC live longer than those with SRC, but the difference was not significant ( P = 0.28). SRC is a histological subtype of gastric carcinoma with distinctive clinicopathologic features. The clinical management of patients should take into account these particular features.