SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse

Aya Uchida; Kenya Imaimatsu; Honoka Suzuki; Xiao Han; Hiroki Ushioda; Mami Uemura; Kasane Imura-Kishi; Ryuji Hiramatsu; Hinako M. Takase; Yoshikazu Hirate; Atsuo Ogura; Masami Kanai-Azuma; Akihiko Kudo; Yoshiakira Kanai

doi:10.1038/s41467-022-35465-1

Nature Communications (Dec 2022)

SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse

Aya Uchida,
Kenya Imaimatsu,
Honoka Suzuki,
Xiao Han,
Hiroki Ushioda,
Mami Uemura,
Kasane Imura-Kishi,
Ryuji Hiramatsu,
Hinako M. Takase,
Yoshikazu Hirate,
Atsuo Ogura,
Masami Kanai-Azuma,
Akihiko Kudo,
Yoshiakira Kanai

Affiliations

Aya Uchida: Department of Veterinary Anatomy, The University of Tokyo
Kenya Imaimatsu: Department of Veterinary Anatomy, The University of Tokyo
Honoka Suzuki: Department of Veterinary Anatomy, The University of Tokyo
Xiao Han: Department of Veterinary Anatomy, The University of Tokyo
Hiroki Ushioda: Department of Veterinary Anatomy, The University of Tokyo
Mami Uemura: Department of Veterinary Anatomy, The University of Tokyo
Kasane Imura-Kishi: Department of Veterinary Anatomy, The University of Tokyo
Ryuji Hiramatsu: Department of Veterinary Anatomy, The University of Tokyo
Hinako M. Takase: Center for Experimental Animals, Tokyo Medical and Dental University
Yoshikazu Hirate: Center for Experimental Animals, Tokyo Medical and Dental University
Atsuo Ogura: Bioresource Engineering Division, RIKEN BioResouce Research Center
Masami Kanai-Azuma: Center for Experimental Animals, Tokyo Medical and Dental University
Akihiko Kudo: Department of Microscopic Anatomy, Kyorin University School of Medicine
Yoshiakira Kanai: Department of Veterinary Anatomy, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-022-35465-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

A valve-like structure called this Sertoli valve (SV) supports spermatogenesis by modulating the directional fluid flow in mouse testis. The SV formation is supported by its neighboring SOX17 + rete testis (RT). This study highlights the essential roles of RT and SV in spermatogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal