CD44 Glycosylation as a Therapeutic Target in Oncology

Chengcheng Liao; Chengcheng Liao; Qian Wang; Qian Wang; Jiaxing An; Jie Chen; Xiaolan Li; Xiaolan Li; Qian Long; Qian Long; Linlin Xiao; Linlin Xiao; Xiaoyan Guan; Xiaoyan Guan; Jianguo Liu; Jianguo Liu

doi:10.3389/fonc.2022.883831

Frontiers in Oncology (Jul 2022)

CD44 Glycosylation as a Therapeutic Target in Oncology

Chengcheng Liao,
Chengcheng Liao,
Qian Wang,
Qian Wang,
Jiaxing An,
Jie Chen,
Xiaolan Li,
Xiaolan Li,
Qian Long,
Qian Long,
Linlin Xiao,
Linlin Xiao,
Xiaoyan Guan,
Xiaoyan Guan,
Jianguo Liu,
Jianguo Liu

Affiliations

Chengcheng Liao: Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China
Chengcheng Liao: Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China
Qian Wang: Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China
Qian Wang: Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Life Sciences Institute, Zunyi Medical University, Zunyi, China
Jiaxing An: Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China
Jie Chen: Department of Urology, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, China
Xiaolan Li: Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China
Xiaolan Li: Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Life Sciences Institute, Zunyi Medical University, Zunyi, China
Qian Long: Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China
Qian Long: Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China
Linlin Xiao: Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China
Linlin Xiao: Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China
Xiaoyan Guan: Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China
Xiaoyan Guan: Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China
Jianguo Liu: Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China
Jianguo Liu: Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China

DOI: https://doi.org/10.3389/fonc.2022.883831
Journal volume & issue: Vol. 12

Abstract

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The interaction of non-kinase transmembrane glycoprotein CD44 with ligands including hyaluronic acid (HA) is closely related to the occurrence and development of tumors. Changes in CD44 glycosylation can regulate its binding to HA, Siglec-15, fibronectin, TM4SF5, PRG4, FGF2, collagen and podoplanin and activate or inhibit c-Src/STAT3/Twist1/Bmi1, PI3K/AKT/mTOR, ERK/NF-κB/NANOG and other signaling pathways, thereby having a profound impact on the tumor microenvironment and tumor cell fate. However, the glycosylation of CD44 is complex and largely unknown, and the current understanding of how CD44 glycosylation affects tumors is limited. These issues must be addressed before targeted CD44 glycosylation can be applied to treat human cancers.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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