Nature Communications (Jan 2017)
A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
- Ning Chai,
- Lee R. Swem,
- Summer Park,
- Gerald Nakamura,
- Nancy Chiang,
- Alberto Estevez,
- Rina Fong,
- Lynn Kamen,
- Elviza Kho,
- Mike Reichelt,
- Zhonghua Lin,
- Henry Chiu,
- Elizabeth Skippington,
- Zora Modrusan,
- Jeremy Stinson,
- Min Xu,
- Patrick Lupardus,
- Claudio Ciferri,
- Man-Wah Tan
Affiliations
- Ning Chai
- Department of Infectious Diseases, Genentech
- Lee R. Swem
- Department of Infectious Diseases, Genentech
- Summer Park
- Department of Translational Immunology, Genentech
- Gerald Nakamura
- Department of Antibody Engineering, Genentech
- Nancy Chiang
- Department of Antibody Engineering, Genentech
- Alberto Estevez
- Department of Structural Biology, Genentech
- Rina Fong
- Department of Structural Biology, Genentech
- Lynn Kamen
- Department of BioAnalytical Sciences, Genentech
- Elviza Kho
- Department of BioAnalytical Sciences, Genentech
- Mike Reichelt
- Department of Pathology, Genentech
- Zhonghua Lin
- Department of Translational Immunology, Genentech
- Henry Chiu
- Department of Biochemical and Cellular Pharmacology, Genentech
- Elizabeth Skippington
- Department of Bioinformatics and Computational Biology, Genentech
- Zora Modrusan
- Department of Molecular Biology, Genentech
- Jeremy Stinson
- Department of Molecular Biology, Genentech
- Min Xu
- Department of Translational Immunology, Genentech
- Patrick Lupardus
- Department of Structural Biology, Genentech
- Claudio Ciferri
- Department of Structural Biology, Genentech
- Man-Wah Tan
- Department of Infectious Diseases, Genentech
- DOI
- https://doi.org/10.1038/ncomms14234
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
Influenza B virus (IBV) co-circulates with influenza A virus to cause annual epidemics. Here, Chaiet al. isolate a human monoclonal antibody that binds to a conserved epitope in the viral HA protein, neutralizes IBV strains in vitro, and protects mice against IBV infection.
