Circadian blood pressure rhythm and polymorphism of G-protein beta 3 subunit in young patients

Abstract

Aim. To investigate the influence of С825Т-polymorphism of G-protein β3 subunit (GNB3) gene on circadian blood pressure (BP) profile among young hypertensive patients with arterial hypertension (AH) in family anamnesis. Material and methods. Sixty-seven young hypertensive patients with AH in family anamnesis, aged 18-33, underwent 24-hour BP monitoring, echocardiography, and GNB3 С825Т-polymorphism genotyping. Then all participants were divided into two groups, according to presence/absence of T allele (ТТ+ТС and СС genotypes, respectively). Results. Prevalence of 825Т allele in the studied population was 0,36. In individuals with 825Т allele, significantly higher levels of systolic BP (SBP), and nighttime temporal index of increased SBP, plus inadequate nighttime SPB decrease, were observed. Patients with ТТ and ТС genotypes demonstrated substantial increase in total peripheral vascular resistance. Conclusion. Individuals with 825Т allele have a high risk of nighttime systolic AH, with poor circadian BP profile.

Keywords

• essential arterial hypertension
• 24-hour blood pressure monitoring
• g-protein
• gnb3 с825т polymorphism