Cardiovascular disease prevalence in climacteric women with carbohydrate metabolism disorders

Abstract

Aim. To assess cardiovascular disease (CVD) prevalence in climacteric women with carbohydrate metabolism disturbances.Material and methods. The case-control study included 468 climacteric women (median age 54,0 years) giving their informed consent. The main group included 234 women with fasting hyperglycemia, FHG (n=133), impaired glucose tolerance, IGT (n=46), and Type 2 diabetes mellitus, DM-2 (n=55). The control group included 234 women without carbohydrate metabolism disturbances, matched by age and post-menopause duration. Anthropometric and lipid profile parameters were measured, arterial hypertension (AH), coronary heart disease (CHD), chronic heart failure (CHF) were registered, as well as strokes and myocardial infarctions in anamnesis.RESULTS. In the main group, prevalence of abdominal obesity, AH, CHD, CHF, and chronic disability was significantly higher. Main group participants also had substantially more severe climacteric syndrome. In FHG females, CHD and CHF were significantly more prevalent than in women with undisturbed carbohydrate metabolism.Conclusion. In climacteric women, carbohydrate metabolism disturbances increase CVD prevalence and aggravate climacteric syndrome.

Keywords

• women
• climacteric period
• carbohydrate metabolism disturbances
• cardiovascular disease