Nature Communications (Sep 2019)
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas
- Shingo Komura,
- Kenji Ito,
- Sho Ohta,
- Tomoyo Ukai,
- Mio Kabata,
- Fumiaki Itakura,
- Katsunori Semi,
- Yutaka Matsuda,
- Kyoichi Hashimoto,
- Hirofumi Shibata,
- Masamitsu Sone,
- Norihide Jo,
- Kazuya Sekiguchi,
- Takatoshi Ohno,
- Haruhiko Akiyama,
- Katsuji Shimizu,
- Knut Woltjen,
- Manabu Ozawa,
- Junya Toguchida,
- Takuya Yamamoto,
- Yasuhiro Yamada
Affiliations
- Shingo Komura
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Kenji Ito
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Sho Ohta
- Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo
- Tomoyo Ukai
- Division of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo
- Mio Kabata
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Fumiaki Itakura
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Katsunori Semi
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Yutaka Matsuda
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Kyoichi Hashimoto
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Hirofumi Shibata
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Masamitsu Sone
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Norihide Jo
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Kazuya Sekiguchi
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Takatoshi Ohno
- Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine
- Haruhiko Akiyama
- Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine
- Katsuji Shimizu
- Spine Center, Gifu Municipal Hospital
- Knut Woltjen
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Manabu Ozawa
- Laboratory of Reproductive Systems Biology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo
- Junya Toguchida
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Takuya Yamamoto
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Yasuhiro Yamada
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- DOI
- https://doi.org/10.1038/s41467-019-11745-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 19
Abstract
The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerves.
