Nature Communications (Jan 2020)

Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

  • Catherine G. Vasilopoulou,
  • Karolina Sulek,
  • Andreas-David Brunner,
  • Ningombam Sanjib Meitei,
  • Ulrike Schweiger-Hufnagel,
  • Sven W. Meyer,
  • Aiko Barsch,
  • Matthias Mann,
  • Florian Meier

DOI
https://doi.org/10.1038/s41467-019-14044-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Trapped ion mobility (TIMS)-mass spectrometry with parallel accumulation-serial fragmentation (PASEF) facilitates high-sensitivity proteomics experiments. Here, the authors expand TIMS and PASEF to small molecules and demonstrate fast and comprehensive lipidomics of low biological sample amounts.