A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations

Gabriel Sturm; Anna S. Monzel; Kalpita R. Karan; Jeremy Michelson; Sarah A. Ware; Andres Cardenas; Jue Lin; Céline Bris; Balaji Santhanam; Michael P. Murphy; Morgan E. Levine; Steve Horvath; Daniel W. Belsky; Shuang Wang; Vincent Procaccio; Brett A. Kaufman; Michio Hirano; Martin Picard

doi:10.1038/s41597-022-01852-y

Scientific Data (Dec 2022)

A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations

Gabriel Sturm,
Anna S. Monzel,
Kalpita R. Karan,
Jeremy Michelson,
Sarah A. Ware,
Andres Cardenas,
Jue Lin,
Céline Bris,
Balaji Santhanam,
Michael P. Murphy,
Morgan E. Levine,
Steve Horvath,
Daniel W. Belsky,
Shuang Wang,
Vincent Procaccio,
Brett A. Kaufman,
Michio Hirano,
Martin Picard

Affiliations

Gabriel Sturm: Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center
Anna S. Monzel: Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center
Kalpita R. Karan: Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center
Jeremy Michelson: Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center
Sarah A. Ware: University of Pittsburgh, School of Medicine, Division of Cardiology, Center for Metabolism and Mitochondrial Medicine and Vascular Medicine Institute
Andres Cardenas: Department of Epidemiology and Population Health, Stanford University
Jue Lin: Department of Biochemistry and Biophysics, University of California
Céline Bris: UMR CNRS 6015, INSERM U1083, MITOVASC, SFR ICAT, Université d’Angers
Balaji Santhanam: Department of Biological Sciences, Columbia University
Michael P. Murphy: MRC-Mitochondrial Biology Unit, University of Cambridge
Morgan E. Levine: Department of Pathology, Yale University School of Medicine
Steve Horvath: Altos Labs
Daniel W. Belsky: Department of Epidemiology & Butler Columbia Aging Center, Columbia University Mailman School of Public Health
Shuang Wang: Department of Biostatistics, Columbia University Irving Medical Center
Vincent Procaccio: UMR CNRS 6015, INSERM U1083, MITOVASC, SFR ICAT, Université d’Angers
Brett A. Kaufman: University of Pittsburgh, School of Medicine, Division of Cardiology, Center for Metabolism and Mitochondrial Medicine and Vascular Medicine Institute
Michio Hirano: Merritt Center and Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Irving Medical Center
Martin Picard: Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center

DOI: https://doi.org/10.1038/s41597-022-01852-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 19

Abstract

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Measurement(s) gene expression assay • DNA Methylation • Telomere Length • Seahorse Bioenergetics • mtDNA copy number • Whole Genome Sequencing • Cytokine • cell-free DNA • mtDNA sequencing • cell-free GDF15 • cell-free IL6 Technology Type(s) Illumina HiSeq. 4000 • Illumina epic array • Real Time PCR • Seahorse XFe96 • Real Time PCR • Luminex 200 • ELISA Factor Type(s) time grown in culture Sample Characteristic - Organism Homo sapiens Sample Characteristic - Environment cell culture Sample Characteristic - Location contiguous United States of America

Published in Scientific Data

ISSN: 2052-4463 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/sdata/

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