CORRELATION C-REACTIVE PROTEIN LEVELS WITH CLINICAL OUTCOME INTRACEREBRAL HEMORRHAGE STROKE PATIENTS

Abstract

Background and aims. Intracerebral hemorrhage stroke remains a major health problem and disability. Increased levels of markers of inflammatory factors after hemorrhage stroke was able to predict poor clinical outcome. Until now, the role of C Reactive Protein (CRP) in the local inflammatory response and clinical determinants output remains unclear. Aims to investigate the correlation of CRP level with poor clinical outcome as measured by Barthel Index. Methods and material. This study was an observasional cohort porspective study performed on haemorrhage stroke patients in Saiful Anwar General Hospital in Februari 2014 until April 2014. Haemorrhage stroke diagnosis was made based on history, neurological examination, and head CT scan on admission. We included 41 patients whom admitted to hospital within 24 h of onset. Neurological examination was performed at early hospitalization, severity degree of stroke was measured by the scale of the National Institute of Health Stroke Scale (NIHSS), at the end of treatment clinical outcome will be assessed with Barthel Index scale. Clinical outcome divided into 2 category, the first is good category (Index Barthel value is between 45-100) and bad category (Index Barthel value is less than 45). C-Reactive Protein value was assessment with high sensitivity (hs) method. Result. There was significant correlation (p=0,01, r=0,613) between CRP levels to poor clinical outcome measured by Barthel Index. Conclusions. C Reactive Protein levels could predict poor clinical outcome as measured by Barthel Index in intracerebral hemorrhage patients.

Keywords

• Intracerebral Haemorrhage stroke
• C-Reactive Protein
• Barthel Index