The level of c-type natriuretic peptide in patients with respiratory cardial comorbidity, depending on genotypes of the gene of endothelial nitric oxide synthase

Abstract

In this work we have studied the level of C-type natriuretic peptide in patients with respiratory cardiac comorbidities (COPD + HD, COPD + IHD), depending on the genotypes (4a/4b and 4b/4b) of the gene of endothelial nitric oxide synthase. Investigation revealed the influence of VNTR-polymorphism on the level of CNUP under the comorbidity combination of COPD + HD, significantly increased production of CNUP, compared with a single disease. At the same time, in patients with COPD + IHD combination of 4а/4b has no significant effect on CNUP production, which is comparable with a single disease (COPD, IHD).

Keywords

• натрийуретический пептид типа С
• дисфункция эндотелия
• хроническая обструктивная болезнь легких
• гипертоническая болезнь
• ишемическая болезнь сердца