Platelet‐derived apoptotic vesicles ameliorate nonalcoholic fatty liver disease by regulating lipid metabolism via apolipoprotein A‐II

Yuhe Jiang; Yike Liao; Zeying Wang; Lei Zhu; Yunsong Liu; Ping Zhang; Yuan Zhu; Wenyue Li; Yongsheng Zhou; Xiao Zhang

doi:10.1002/INMD.20240059

Interdisciplinary Medicine (Jan 2025)

Platelet‐derived apoptotic vesicles ameliorate nonalcoholic fatty liver disease by regulating lipid metabolism via apolipoprotein A‐II

Yuhe Jiang,
Yike Liao,
Zeying Wang,
Lei Zhu,
Yunsong Liu,
Ping Zhang,
Yuan Zhu,
Wenyue Li,
Yongsheng Zhou,
Xiao Zhang

Affiliations

Yuhe Jiang: Department of Prosthodontics Peking University School and Hospital of Stomatology National Center of Stomatology National Clinical Research Center for Oral Disease National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health NMPA Key Laboratory for Dental Materials Beijing China
Yike Liao: Department of Prosthodontics Peking University School and Hospital of Stomatology National Center of Stomatology National Clinical Research Center for Oral Disease National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health NMPA Key Laboratory for Dental Materials Beijing China
Zeying Wang: Department of Prosthodontics Peking University School and Hospital of Stomatology National Center of Stomatology National Clinical Research Center for Oral Disease National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health NMPA Key Laboratory for Dental Materials Beijing China
Lei Zhu: Department of Prosthodontics Peking University School and Hospital of Stomatology National Center of Stomatology National Clinical Research Center for Oral Disease National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health NMPA Key Laboratory for Dental Materials Beijing China
Yunsong Liu: Department of Prosthodontics Peking University School and Hospital of Stomatology National Center of Stomatology National Clinical Research Center for Oral Disease National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health NMPA Key Laboratory for Dental Materials Beijing China
Ping Zhang: Department of Prosthodontics Peking University School and Hospital of Stomatology National Center of Stomatology National Clinical Research Center for Oral Disease National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health NMPA Key Laboratory for Dental Materials Beijing China
Yuan Zhu: Department of Stomatology Peking University Third Hospital Beijing China
Wenyue Li: Department of Stomatology Beijing Chao‐Yang Hospital Capital Medical University Beijing China
Yongsheng Zhou: Department of Prosthodontics Peking University School and Hospital of Stomatology National Center of Stomatology National Clinical Research Center for Oral Disease National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health NMPA Key Laboratory for Dental Materials Beijing China
Xiao Zhang: Department of Prosthodontics Peking University School and Hospital of Stomatology National Center of Stomatology National Clinical Research Center for Oral Disease National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health NMPA Key Laboratory for Dental Materials Beijing China

DOI: https://doi.org/10.1002/INMD.20240059
Journal volume & issue: Vol. 3, no. 1
pp. n/a – n/a

Abstract

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Abstract Nonalcoholic fatty liver disease (NAFLD) encompasses a broad range of conditions, commencing with simple steatosis and progressing to non‐alcoholic steatohepatitis, with the possibility of further deterioration into fibrosis, cirrhosis, and ultimately, hepatocellular carcinoma. Unfortunately, there is currently no approved medication for treating NAFLD‐associated liver steatosis. This underscores the need for improved therapeutic approaches that can modulate lipid metabolism and halt the transition from liver steatosis to chronic liver disease. Our previous studies have demonstrated that apoptotic vesicles (apoVs), which are produced during apoptosis, show great potential in regulating liver homeostasis. However, whether they can ameliorate NAFLD is unknown. In our research, apoVs derived from platelets (PLT‐apoVs) as well as apoVs derived from mesenchymal stem cells (MSC‐apoVs) were used to treat NAFLD. The results showed that PLT‐apoVs exhibited superior effects in diminishing lipid accumulation in liver induced by high‐fat diet than MSC‐apoVs. Through proteomic analysis, we defined and validated apolipoprotein A‐II (APOA2) as a regulator for apoV‐mediated MSC adipogenesis, which could be used as a target to enhance apoV therapeutic potential in the lipid metabolism biomedical field. Owing to the higher expression of APOA2, PLT‐apoVs showed better therapeutic effects than MSC‐apoVs. Our results pave the way to apoV‐based therapy for NAFLD.

Published in Interdisciplinary Medicine

ISSN: 2832-6237 (Print); 2832-6245 (Online)
Publisher: Wiley-VCH
Country of publisher: Germany
LCC subjects: Medicine: Medicine (General): Medical technology; Technology: Chemical technology: Biotechnology
Website: https://onlinelibrary.wiley.com/journal/28326245

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