Combination of Ensembles of Regularized Regression Models with Resampling-Based Lasso Feature Selection in High Dimensional Data

Abstract

In high-dimensional data, the performances of various classifiers are largely dependent on the selection of important features. Most of the individual classifiers with the existing feature selection (FS) methods do not perform well for highly correlated data. Obtaining important features using the FS method and selecting the best performing classifier is a challenging task in high throughput data. In this article, we propose a combination of resampling-based least absolute shrinkage and selection operator (LASSO) feature selection (RLFS) and ensembles of regularized regression (ERRM) capable of dealing data with the high correlation structures. The ERRM boosts the prediction accuracy with the top-ranked features obtained from RLFS. The RLFS utilizes the lasso penalty with sure independence screening (SIS) condition to select the top k ranked features. The ERRM includes five individual penalty based classifiers: LASSO, adaptive LASSO (ALASSO), elastic net (ENET), smoothly clipped absolute deviations (SCAD), and minimax concave penalty (MCP). It was built on the idea of bagging and rank aggregation. Upon performing simulation studies and applying to smokers’ cancer gene expression data, we demonstrated that the proposed combination of ERRM with RLFS achieved superior performance of accuracy and geometric mean.

Keywords

• ensembles
• feature selection
• high-throughput
• gene expression data
• resampling
• lasso
• adaptive lasso
• elastic net
• scad
• mcp