Nature Communications (Mar 2016)
IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis
- Rossana G. Iannitti,
- Valerio Napolioni,
- Vasilis Oikonomou,
- Antonella De Luca,
- Claudia Galosi,
- Marilena Pariano,
- Cristina Massi-Benedetti,
- Monica Borghi,
- Matteo Puccetti,
- Vincenzina Lucidi,
- Carla Colombo,
- Ersilia Fiscarelli,
- Cornelia Lass-Flörl,
- Fabio Majo,
- Lisa Cariani,
- Maria Russo,
- Luigi Porcaro,
- Gabriella Ricciotti,
- Helmut Ellemunter,
- Luigi Ratclif,
- Fernando Maria De Benedictis,
- Vincenzo Nicola Talesa,
- Charles A. Dinarello,
- Frank L. van de Veerdonk,
- Luigina Romani
Affiliations
- Rossana G. Iannitti
- Department of Experimental Medicine, University of Perugia
- Valerio Napolioni
- Department of Experimental Medicine, University of Perugia
- Vasilis Oikonomou
- Department of Experimental Medicine, University of Perugia
- Antonella De Luca
- Department of Experimental Medicine, University of Perugia
- Claudia Galosi
- Department of Experimental Medicine, University of Perugia
- Marilena Pariano
- Department of Experimental Medicine, University of Perugia
- Cristina Massi-Benedetti
- Department of Experimental Medicine, University of Perugia
- Monica Borghi
- Department of Experimental Medicine, University of Perugia
- Matteo Puccetti
- Department of Experimental Medicine, University of Perugia
- Vincenzina Lucidi
- Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital
- Carla Colombo
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan
- Ersilia Fiscarelli
- Children's Hospital Bambino Gesù IRCCS
- Cornelia Lass-Flörl
- Division of Hygiene and Medical Microbiology, Innsbruck Medical University
- Fabio Majo
- Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital
- Lisa Cariani
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan
- Maria Russo
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan
- Luigi Porcaro
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan
- Gabriella Ricciotti
- Children's Hospital Bambino Gesù IRCCS
- Helmut Ellemunter
- CF Centre, Medical University Innsbruck
- Luigi Ratclif
- Servizio di Supporto Fibrosi Cistica, Istituto Ospedale G. Tatarella
- Fernando Maria De Benedictis
- Department of Mother and Child Health, Salesi Children’s Hospital
- Vincenzo Nicola Talesa
- Department of Experimental Medicine, University of Perugia
- Charles A. Dinarello
- Radboud Center for Infectious Diseases
- Frank L. van de Veerdonk
- Division of Infectious Diseases, University of Colorado Denver
- Luigina Romani
- Department of Experimental Medicine, University of Perugia
- DOI
- https://doi.org/10.1038/ncomms10791
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
IL-1-mediated inflammation contributes to the pathogenesis of cystic fibrosis. Here the authors show that this is largely due to NLRP3 activation, whereas NLRP4 induces IL-1Ra, limiting the overall inflammasome activity and providing a therapeutic angle to ameliorate the disease.
