Data on miRNome changes in human cells exposed to nano- or ionic- forms of Cadmium
Laura Paesano,
Marta Marmiroli,
Massimiliano G. Bianchi,
Jason C. White,
Ovidio Bussolati,
Andrea Zappettini,
Marco Villani,
Nelson Marmiroli
Affiliations
Laura Paesano
University of Parma, Department of Chemistry, Life Sciences and Environmental Sustainability, Parco Area delle Scienze 11/A, 43124 Parma, Italy
Marta Marmiroli
University of Parma, Department of Chemistry, Life Sciences and Environmental Sustainability, Parco Area delle Scienze 11/A, 43124 Parma, Italy
Massimiliano G. Bianchi
University of Parma, Department of Medicine and Surgery, Laboratory of General Pathology, Via Volturno 39, 43125 Parma, Italy
Jason C. White
Department of Analytical Chemistry, The Connecticut Agricultural Experiment Station (CAES), New Haven, Connecticut 06504, United States
Ovidio Bussolati
University of Parma, Department of Medicine and Surgery, Laboratory of General Pathology, Via Volturno 39, 43125 Parma, Italy
Andrea Zappettini
Institute of Materials for Electronics and Magnetism (IMEM-CNR), Parco Area delle Scienze 37/A, 43124 Parma, Italy
Marco Villani
Institute of Materials for Electronics and Magnetism (IMEM-CNR), Parco Area delle Scienze 37/A, 43124 Parma, Italy
Nelson Marmiroli
University of Parma, Department of Chemistry, Life Sciences and Environmental Sustainability, Parco Area delle Scienze 11/A, 43124 Parma, Italy; National Interuniversity Consortium for Environmental Sciences (CINSA), Parco Area delle Scienze 93/A, 43124 Parma, Italy Parma, Italy; Corresponding author(s).
The data included in this paper are associated with a research article entitled 'Differences in toxicity, mitochondrial function and miRNome in human cells exposed in vitro to Cd as CdS quantum dots or ionic Cd' [1]. The article concerns the use of miRNAs as biomarkers for engineered nanomaterials (ENMs) risk assessment. Two different type of human cells, HepG2 and THP-1, were exposed to different forms of Cadmium: nanoscale, as CdS quantum dots (CdS QDs), and ionic, as CdSO4 8/3 –hydrate (Cd(II)). The cells were treated with sub-toxic doses of CdS QDs; 3 µg ml−1 in HepG2 and 6.4 µg ml−1 and 50 µg ml−1 in THP-1, as well as equivalent cadmium doses as Cd(II). In this dataset, changes in expression levels of miRNAs are reported. In addition, GO enrichment analyses of target genes of miRNAs modulated by Cd stress, network analysis of the microRNome and an in silico pathway analysis are also reported. These data enhance and also summarize much of the data independently presented in the research article and therefore, must be considered as supplementary.
