Nature Communications (Dec 2017)
ORAI channels are critical for receptor-mediated endocytosis of albumin
- Bo Zeng,
- Gui-Lan Chen,
- Eliana Garcia-Vaz,
- Sunil Bhandari,
- Nikoleta Daskoulidou,
- Lisa M. Berglund,
- Hongni Jiang,
- Thomas Hallett,
- Lu-Ping Zhou,
- Li Huang,
- Zi-Hao Xu,
- Viji Nair,
- Robert G. Nelson,
- Wenjun Ju,
- Matthias Kretzler,
- Stephen L. Atkin,
- Maria F. Gomez,
- Shang-Zhong Xu
Affiliations
- Bo Zeng
- Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull
- Gui-Lan Chen
- Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull
- Eliana Garcia-Vaz
- Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University
- Sunil Bhandari
- Department of Renal Medicine and Hull York Medical School, Hull Royal Infirmary, Hull and East Yorkshire Hospitals NHS Trust
- Nikoleta Daskoulidou
- Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull
- Lisa M. Berglund
- Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University
- Hongni Jiang
- Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull
- Thomas Hallett
- Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull
- Lu-Ping Zhou
- Key Laboratory of Medical Electrophysiology, Ministry of Education, and Institute of Cardiovascular Research, Southwest Medical University
- Li Huang
- Key Laboratory of Medical Electrophysiology, Ministry of Education, and Institute of Cardiovascular Research, Southwest Medical University
- Zi-Hao Xu
- Key Laboratory of Medical Electrophysiology, Ministry of Education, and Institute of Cardiovascular Research, Southwest Medical University
- Viji Nair
- Department of Internal Medicine & Department of Computational Medicine and Bioinformatics, University of Michigan
- Robert G. Nelson
- Chronic Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
- Wenjun Ju
- Department of Internal Medicine & Department of Computational Medicine and Bioinformatics, University of Michigan
- Matthias Kretzler
- Department of Internal Medicine & Department of Computational Medicine and Bioinformatics, University of Michigan
- Stephen L. Atkin
- Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull
- Maria F. Gomez
- Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University
- Shang-Zhong Xu
- Centre for Cardiovascular and Metabolic Research, Hull York Medical School, University of Hull
- DOI
- https://doi.org/10.1038/s41467-017-02094-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.
