Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

Poorya Amini; Darko Stojkov; Andrea Felser; Christopher B. Jackson; Carolina Courage; André Schaller; Laurent Gelman; Maria Eugenia Soriano; Jean-Marc Nuoffer; Luca Scorrano; Charaf Benarafa; Shida Yousefi; Hans-Uwe Simon

doi:10.1038/s41467-018-05387-y

Nature Communications (Jul 2018)

Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

Poorya Amini,
Darko Stojkov,
Andrea Felser,
Christopher B. Jackson,
Carolina Courage,
André Schaller,
Laurent Gelman,
Maria Eugenia Soriano,
Jean-Marc Nuoffer,
Luca Scorrano,
Charaf Benarafa,
Shida Yousefi,
Hans-Uwe Simon

Affiliations

Poorya Amini: Institute of Pharmacology, University of Bern
Darko Stojkov: Institute of Pharmacology, University of Bern
Andrea Felser: University Institute of Clinical Chemistry, Bern University Hospital
Christopher B. Jackson: Research Program for Molecular Neurology, Biomedicum Helsinki, University of Helsinki
Carolina Courage: Division of Human Genetics and Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern
André Schaller: Division of Human Genetics and Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern
Laurent Gelman: Friedrich Miescher Institute for Biomedical Research
Maria Eugenia Soriano: Department of Biology, University of Padua
Jean-Marc Nuoffer: University Institute of Clinical Chemistry, Bern University Hospital
Luca Scorrano: Venetian Institute of Molecular Medicine (VIMM)
Charaf Benarafa: Institute of Virology and Immunology
Shida Yousefi: Institute of Pharmacology, University of Bern
Hans-Uwe Simon: Institute of Pharmacology, University of Bern

DOI: https://doi.org/10.1038/s41467-018-05387-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Optic atrophy 1 (OPA1) is known to be important for mitochondrial fusion and structural integrity. Here, using OPA1 knockout mice, the authors show a detrimental effect on host defense capabilities against pathogen infections. This study reports a critical role for OPA1 in innate immunity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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