A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress

Pietro Cacialli; Christopher B. Mahony; Tim Petzold; Patrizia Bordignon; Anne-Laure Rougemont; Julien Y. Bertrand

doi:10.1038/s41467-021-24831-0

Nature Communications (Jul 2021)

A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress

Pietro Cacialli,
Christopher B. Mahony,
Tim Petzold,
Patrizia Bordignon,
Anne-Laure Rougemont,
Julien Y. Bertrand

Affiliations

Pietro Cacialli: University of Geneva, Faculty of Medicine, Department of Pathology and Immunology
Christopher B. Mahony: University of Geneva, Faculty of Medicine, Department of Pathology and Immunology
Tim Petzold: University of Geneva, Faculty of Medicine, Department of Pathology and Immunology
Patrizia Bordignon: Division of clinical pathology, Geneva University Hospitals
Anne-Laure Rougemont: Division of clinical pathology, Geneva University Hospitals
Julien Y. Bertrand: University of Geneva, Faculty of Medicine, Department of Pathology and Immunology

DOI: https://doi.org/10.1038/s41467-021-24831-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

Read online

Reactive oxygen species (ROS) are metabolic by-products which in excess can be toxic for hematopoietic stem and progenitor cells (HSPCs). Here the authors show that toxic ROS are transferred by expanding HSPCs to the zebrafish developmental niche via connexin Cx41.8, where Ifi30 promotes their detoxification.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal