Nature Communications (Oct 2022)
Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice
- Tian Zhou,
- Yuxin Li,
- Xiaoyu Li,
- Fanzhuo Zeng,
- Yanxia Rao,
- Yang He,
- Yafei Wang,
- Meizhen Liu,
- Dali Li,
- Zhen Xu,
- Xin Zhou,
- Siling Du,
- Fugui Niu,
- Jiyun Peng,
- Xifan Mei,
- Sheng-Jian Ji,
- Yousheng Shu,
- Wei Lu,
- Feifan Guo,
- Tianzhun Wu,
- Ti-Fei Yuan,
- Ying Mao,
- Bo Peng
Affiliations
- Tian Zhou
- Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
- Yuxin Li
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- Xiaoyu Li
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- Fanzhuo Zeng
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- Yanxia Rao
- Department of Laboratory Animal Science, MOE Frontiers Center for Brain Science, Fudan University
- Yang He
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- Yafei Wang
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- Meizhen Liu
- Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University
- Dali Li
- Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University
- Zhen Xu
- Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
- Xin Zhou
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- Siling Du
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- Fugui Niu
- School of Life Sciences, Department of Biology, Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Brain Research Center, Southern University of Science and Technology
- Jiyun Peng
- Institute of Life Science, Nanchang University
- Xifan Mei
- Department of Orthopedics, The Third Affiliated Hospital of Jinzhou Medical University
- Sheng-Jian Ji
- School of Life Sciences, Department of Biology, Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Brain Research Center, Southern University of Science and Technology
- Yousheng Shu
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- Wei Lu
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- Feifan Guo
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- Tianzhun Wu
- Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
- Ti-Fei Yuan
- Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Ying Mao
- Department of Neurosurgery, Huashan Hospital, Fudan University
- Bo Peng
- Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University
- DOI
- https://doi.org/10.1038/s41467-022-33932-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Microglia are professional phagocytes in the CNS. However, which cells scavenge corpses of microglia is largely neglected. Peng and colleagues found that nonprofessional phagocytes (astrocyte) phagocytose the debris of professional phagocytes (microglia).
