Marine Drugs (Nov 2014)

Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii

  • Zheng-Xi Hu,
  • Yong-Bo Xue,
  • Xiao-Bin Bi,
  • Jin-Wen Zhang,
  • Zeng-Wei Luo,
  • Xiao-Nian Li,
  • Guang-Min Yao,
  • Jian-Ping Wang,
  • Yong-Hui Zhang

DOI
https://doi.org/10.3390/md12115563
Journal volume & issue
Vol. 12, no. 11
pp. 5563 – 5575

Abstract

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Five new compounds, including a benzopyran ribonic glycoside, daldiniside A (1), two isocoumarin ribonic glycosides, daldinisides B (2) and C (3), and two alkaloids, 1-(3-indolyl)-2R,3-dihydroxypropan-1-one (4) and 3-ethyl-2, 5-pyrazinedipropanoic acid (5), along with five known compounds (6–10), were isolated from the EtOAc extract of the marine-associated fungus, Daldinia eschscholzii. Their structures were elucidated by extensive physicochemical and spectroscopic properties, besides comparison with literature data. The absolute configurations of compounds 1–3 were corroborated by chemical transformation, GC analysis and X-ray crystallographic analysis. Meanwhile, the absolute configuration of compound 4 and the planar structure of compound 6 were also determined based on the X-ray diffraction analysis. The cytotoxicity of compounds 1–10, antifungal and anti-HIV activities of compounds 1–5 and the in vitro assay for glucose consumption of compounds 1–3 were done in the anti-diabetic model, whereas none showed obvious activity.

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