Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway

Abstract

Within the MAPK/RAS pathway, there exists a plethora of protein–protein interactions (PPIs). For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes to provide much needed therapies for patients with KRAS-mutant driven cancers. In this review, we focus on recent strategies to inhibit RAS-signaling via disrupting PPIs associated with SOS1, RAF, PDEδ, Grb2, and RAS.

Keywords

• MAPK
• KRAS
• RAS
• protein–protein interactions
• X-ray crystallography