COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks

Amila Suraweera; Neha S. Gandhi; Sam Beard; Joshua T. Burgess; Laura V. Croft; Emma Bolderson; Ali Naqi; Nicholas W. Ashton; Mark N. Adams; Kienan I. Savage; Shu-Dong Zhang; Kenneth J. O’Byrne; Derek J. Richard

doi:10.1038/s42003-021-01998-2

Communications Biology (Apr 2021)

COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks

Amila Suraweera,
Neha S. Gandhi,
Sam Beard,
Joshua T. Burgess,
Laura V. Croft,
Emma Bolderson,
Ali Naqi,
Nicholas W. Ashton,
Mark N. Adams,
Kienan I. Savage,
Shu-Dong Zhang,
Kenneth J. O’Byrne,
Derek J. Richard

Affiliations

Amila Suraweera: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute
Neha S. Gandhi: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute
Sam Beard: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute
Joshua T. Burgess: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute
Laura V. Croft: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute
Emma Bolderson: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute
Ali Naqi: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute
Nicholas W. Ashton: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute
Mark N. Adams: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute
Kienan I. Savage: The Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast
Shu-Dong Zhang: Northern Ireland Centre for Stratified Medicine, University of Ulster
Kenneth J. O’Byrne: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute
Derek J. Richard: Queensland University of Technology (QUT), School of Biomedical Sciences, Centre for Genomics and Personalised Health at the Translational Research Institute

DOI: https://doi.org/10.1038/s42003-021-01998-2
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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Amila Suraweera et al. use a range of biochemical and in vitro cellular assays to examine the role of the COMMD4 in DNA repair. Their results suggest that COMMD4 interacts with the histone H2A-H2B during repair of double-stranded DNA breaks, thereby maintaining genomic stability by regulating chromatin structure.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal