PLoS Pathogens (Jan 2019)

Roles, function and relevance of LAG3 in HIV infection.

  • Colin G Graydon,
  • Allison L Balasko,
  • Keith R Fowke

DOI
https://doi.org/10.1371/journal.ppat.1007429
Journal volume & issue
Vol. 15, no. 1
p. e1007429

Abstract

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HIV causes several forms of immune dysfunction that need to be addressed in a functional cure for HIV. Immune exhaustion describes a dysfunctional phenotype caused by chronic cellular activation. Lymphocyte activation gene-3 (LAG3) is one of several negative coreceptors known as immune checkpoints that contribute to this exhaustion phenotype. Antibodies targeting immune checkpoints are now used clinically to restore immunity against cancer and hold promise in restoring immunity during HIV infection. Here, we summarize current knowledge surrounding LAG3 and discuss its relevance during HIV infection and the potential for LAG3-targeting antibodies in a functional HIV cure.