Nature Communications (Jan 2016)
Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes
- Hernan Lorenzi,
- Asis Khan,
- Michael S. Behnke,
- Sivaranjani Namasivayam,
- Lakshmipuram S. Swapna,
- Michalis Hadjithomas,
- Svetlana Karamycheva,
- Deborah Pinney,
- Brian P. Brunk,
- James W. Ajioka,
- Daniel Ajzenberg,
- John C. Boothroyd,
- Jon P. Boyle,
- Marie L. Dardé,
- Maria A. Diaz-Miranda,
- Jitender P. Dubey,
- Heather M. Fritz,
- Solange M. Gennari,
- Brian D. Gregory,
- Kami Kim,
- Jeroen P. J. Saeij,
- Chunlei Su,
- Michael W. White,
- Xing-Quan Zhu,
- Daniel K. Howe,
- Benjamin M. Rosenthal,
- Michael E. Grigg,
- John Parkinson,
- Liang Liu,
- Jessica C. Kissinger,
- David S. Roos,
- L. David Sibley
Affiliations
- Hernan Lorenzi
- Department of Infectious Diseases, The J. Craig Venter Institute, 9704 Medical Center Drive
- Asis Khan
- Department of Molecular Microbiology, Washington University School of Medicine
- Michael S. Behnke
- Department of Molecular Microbiology, Washington University School of Medicine
- Sivaranjani Namasivayam
- Department of Genetics, University of Georgia
- Lakshmipuram S. Swapna
- Program in Molecular Structure and Function, Hospital for Sick Children
- Michalis Hadjithomas
- Department of Infectious Diseases, The J. Craig Venter Institute, 9704 Medical Center Drive
- Svetlana Karamycheva
- Department of Infectious Diseases, The J. Craig Venter Institute, 9704 Medical Center Drive
- Deborah Pinney
- Department of Biology, University of Pennsylvania
- Brian P. Brunk
- Department of Biology, University of Pennsylvania
- James W. Ajioka
- Department of Pathology, University of Cambridge
- Daniel Ajzenberg
- Biological Resource Center for Toxoplasma, INSERM, University Limoges, CHU Limoges, UMR_S 1094, Tropical Neuroepidemiology, Institute of Neuroepidemiology and Tropical Neurology
- John C. Boothroyd
- Department of Microbiology and Immunology, Stanford School of Medicine
- Jon P. Boyle
- Department of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh
- Marie L. Dardé
- Biological Resource Center for Toxoplasma, INSERM, University Limoges, CHU Limoges, UMR_S 1094, Tropical Neuroepidemiology, Institute of Neuroepidemiology and Tropical Neurology
- Maria A. Diaz-Miranda
- Department of Biology, University of Pennsylvania
- Jitender P. Dubey
- Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA
- Heather M. Fritz
- Department of Veterinary Pathology and Microbiology, Washington State University, College of Veterinary Medicine
- Solange M. Gennari
- Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine, University of São Paulo
- Brian D. Gregory
- Department of Biology, University of Pennsylvania
- Kami Kim
- Departments of Medicine, Pathology, and Microbiology and Immunology, Albert Einstein College of Medicine
- Jeroen P. J. Saeij
- Department of Pathology, Microbiology & Immunology, University of California
- Chunlei Su
- Department of Microbiology, University of Tennessee
- Michael W. White
- Departments of Molecular Medicine and Global Health, Florida Center for Drug Discovery and Development (CDDI), University of South Florida
- Xing-Quan Zhu
- State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
- Daniel K. Howe
- Department of Veterinary Science, University of Kentucky
- Benjamin M. Rosenthal
- Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA
- Michael E. Grigg
- Laboratory of Parasitic Diseases, NIAID, National Institutes of Health
- John Parkinson
- Program in Molecular Structure and Function, Hospital for Sick Children
- Liang Liu
- Department of Statistics, University of Georgia
- Jessica C. Kissinger
- Department of Genetics, University of Georgia
- David S. Roos
- Department of Biology, University of Pennsylvania
- L. David Sibley
- Department of Molecular Microbiology, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms10147
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Toxoplasma gondii is a parasite that causes zoonotic infections in humans. Here, the authors identify tandem amplification and diversification of secretory pathogenesis determinants in the T. gondiigenome and show that clade-specific inheritance of conserved haploblocks enriched for these determinants shapes population structure.
