EXCLI Journal : Experimental and Clinical Sciences (Jul 2023)

Circular RNAs

  • Mina Alimohammadi,
  • Yasaman Gholinezhad,
  • Vahide Mousavi,
  • Samaneh Kahkesh,
  • Malihe Rezaee,
  • Alireza Yaghoobi,
  • Alireza Mafi,
  • Mahmood Araghi

DOI
https://doi.org/10.17179/excli2023-6209
Journal volume & issue
Vol. 22
pp. 645 – 669

Abstract

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Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the interaction of the Wnt/β-catenin pathway, which regulates several biological processes involved in tumorigenesis, thereby contributing to the development and progression of cancer. Interactions of tumor-derived circRNAs with the Wnt/β-catenin signaling pathway provide both clinical diagnostic biomarkers and promising therapeutic targets. In this review, we outlined current evidence on the roles of circRNAs associated with the Wnt/β-catenin pathway in regulating lung cancer formation and development. We believe that our findings will assist in the advancement or establishment of circRNA-based lung cancer therapeutic approaches.

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