Isolation of triazole-resistant Aspergillus fumigatus harbouring cyp51A mutations from five patients with invasive pulmonary aspergillosis in Yunnan, China
Hui Xu,
Yuhong Gao,
Tianyu Liang,
Qiqi Wang,
Zhe Wan,
Ruoyu Li,
Wei Liu
Affiliations
Hui Xu
Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
Yuhong Gao
Department of clinical laboratory, The First People’s Hospital of Yunnan Province, Kunming, China
Tianyu Liang
Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
Qiqi Wang
Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
Zhe Wan
Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
Ruoyu Li
Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
Wei Liu
Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China
Invasive aspergillosis (IA) is the most severe type of Aspergillus infection. Yunnan has developed agriculture, and the proportion of triazole-resistant A. fumigatus induced by triazole fungicides is much higher than that in other regions of China. Inhalation of triazole-resistant A. fumigatus is one of the main factors inducing IA. We gathered five strains of A. fumigatus from the sputum or bronchoalveolar lavage fluid (BALF) of patients with IA in Yunnan. Subsequent testing showed that all of these strains were resistant to triazoles and harboured mutations in the tandem repeat sequence of the cyp51A promoter region, suggesting that they may be triazole-resistant A. fumigatus present in the environment.
