iScience (May 2022)
Distinct miRNAs associated with various clinical presentations of SARS-CoV-2 infection
- Qiqi Zeng,
- Xin Qi,
- Junpeng Ma,
- Fang Hu,
- Xiaorui Wang,
- Hongyu Qin,
- Mengyang Li,
- Shaoxin Huang,
- Yong Yang,
- Yixin Li,
- Han Bai,
- Meng Jiang,
- Doudou Ren,
- Ye Kang,
- Yang Zhao,
- Xiaobei Chen,
- Xi Ding,
- Di Ye,
- Yankui Wang,
- Jianguo Jiang,
- Dong Li,
- Xi Chen,
- Ke Hu,
- Binghong Zhang,
- Bingyin Shi,
- Chengsheng Zhang
Affiliations
- Qiqi Zeng
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Xin Qi
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Junpeng Ma
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Fang Hu
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Xiaorui Wang
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Hongyu Qin
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Mengyang Li
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Shaoxin Huang
- SpecAlly Life Technology Co, Ltd, Wuhan East Lake High-tech Development Zone, 666 Gaoxin Road, Wuhan 430075, China
- Yong Yang
- SpecAlly Life Technology Co, Ltd, Wuhan East Lake High-tech Development Zone, 666 Gaoxin Road, Wuhan 430075, China
- Yixin Li
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Han Bai
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Meng Jiang
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Doudou Ren
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Ye Kang
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China
- Yang Zhao
- Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan 430060, China
- Xiaobei Chen
- Department of Infectious Diseases, The Renmin Hospital of Wuhan University, East Campus, East Lake New Technology Development Zone, Gaoxin 6th Road, Wuhan 430040, China
- Xi Ding
- Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China
- Di Ye
- Department of Rehabilitation, The Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan 430060, China
- Yankui Wang
- Dialysis Center, The Renmin Hospital of Wuhan University, East Campus, East Lake New Technology Development Zone, Gaoxin 6th Road, Wuhan 430040, China
- Jianguo Jiang
- LC-Bio Technologies (Hangzhou) Co., Ltd., Hanghzhou 310000, China
- Dong Li
- Department of Clinical Laboratory, The Renmin Hospital of Wuhan University, East Campus, East Lake New Technology Development Zone, Gaoxin 6th Road, Wuhan 430040, China
- Xi Chen
- SpecAlly Life Technology Co, Ltd, Wuhan East Lake High-tech Development Zone, 666 Gaoxin Road, Wuhan 430075, China; Wuhan Institute of Biotechnology, Wuhan East Lake High-tech Development Zone, 666 Gaoxin Road, Wuhan 430040, China; Corresponding author
- Ke Hu
- Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan 430060, China; Corresponding author
- Binghong Zhang
- The Renmin Hospital of Wuhan University, East Campus, East Lake New Technology Development Zone, Gaoxin 6th Road, Wuhan 430040, China; Corresponding author
- Bingyin Shi
- Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; Corresponding author
- Chengsheng Zhang
- Precision Medicine Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The MED-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Western China Science and Technology Innovation Harbor, Building 21, Xi’an 710000, China; Cancer Center, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an 710061, China; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Corresponding author
- Journal volume & issue
-
Vol. 25,
no. 5
p. 104309
Abstract
Summary: MicroRNAs (miRNAs) have been shown to play important roles in viral infections, but their associations with SARS-CoV-2 infection remain poorly understood. Here, we detected 85 differentially expressed miRNAs (DE-miRNAs) from 2,336 known and 361 novel miRNAs that were identified in 233 plasma samples from 61 healthy controls and 116 patients with COVID-19 using the high-throughput sequencing and computational analysis. These DE-miRNAs were associated with SASR-CoV-2 infection, disease severity, and viral persistence in the patients with COVID-19, respectively. Gene ontology and KEGG pathway analyses of the DE-miRNAs revealed their connections to viral infections, immune responses, and lung diseases. Finally, we established a machine learning model using the DE-miRNAs between various groups for classification of COVID-19 cases with different clinical presentations. Our findings may help understand the contribution of miRNAs to the pathogenesis of COVID-19 and identify potential biomarkers and molecular targets for diagnosis and treatment of SARS-CoV-2 infection.
