Oral submucous fibrosis associated oral squamous cell carcinoma: A case report with review of literature

Abstract

Oral submucous fibrosis (OSMF) is a chronic, insidious premalignant disease associated with significant functional morbidity and an increased risk for malignancy. The oral squamous cell carcinoma (OSCC) originated from OSMF are tend to be highly invasive, metastatic & well differentiated. Here, we report a case of a Bangladeshi female having a long history of areca nut chewing and was diagnosed with OSMF-associated OSCC. Histologically, the tissue biopsy showed evidence of dense fibrosis and presence of islands of atypical squamous cells in the subepithelial region. The clinical and radiological findings also support the evidence of OSMF-associated OSCC in patient.

Keywords

• Oral submucous fibrosis
• Oral squamous cell carcinoma
• Malignant transformation