The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
Yinhe Mao
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China; The University of Chinese Academy of Sciences, Beijing, China
Xiaoqing Chen
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China; The University of Chinese Academy of Sciences, Beijing, China
Xinhuang Huang
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
Zhongyi Jiang
Department of General Surgery, Shanghai General Hospital, Shanghai, China
Kaiyan Yang
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China; The University of Chinese Academy of Sciences, Beijing, China
Lixing Tian
State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Army Medical Center (Daping Hospital), Chongqing, China
Tong Jiang
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
Yun Zou
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
Xiaoyuan Ma
State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Army Medical Center (Daping Hospital), Chongqing, China
Chaoyue Xu
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China; College of Life Science, Shanghai, China
Zili Zhou
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
Xianwei Wu
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China; The University of Chinese Academy of Sciences, Beijing, China
Lei Pan
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
Huaping Liang
State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Army Medical Center (Daping Hospital), Chongqing, China
Lin Zhong
Department of General Surgery, Shanghai General Hospital, Shanghai, China
The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
The transition metal iron plays a crucial role in living cells. However, high levels of iron are potentially toxic through the production of reactive oxygen species (ROS), serving as a deterrent to the commensal fungus Candida albicans for colonization in the iron-rich gastrointestinal tract. We observe that the mutant lacking an iron-responsive transcription factor Hap43 is hyper-fit for colonization in murine gut. We demonstrate that high iron specifically triggers multiple post-translational modifications and proteasomal degradation of Hap43, a vital process guaranteeing the precision of intestinal ROS detoxification. Reduced levels of Hap43 de-repress the expression of antioxidant genes and therefore alleviate the deleterious ROS derived from iron metabolism. Our data reveal that Hap43 functions as a negative regulator for oxidative stress adaptation of C. albicans to gut colonization and thereby provide a new insight into understanding the interplay between iron homeostasis and fungal commensalism.
