Nature Communications (Jul 2021)

CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

  • Yuzo Koda,
  • Toshiaki Teratani,
  • Po-Sung Chu,
  • Yuya Hagihara,
  • Yohei Mikami,
  • Yosuke Harada,
  • Hanako Tsujikawa,
  • Kentaro Miyamoto,
  • Takahiro Suzuki,
  • Nobuhito Taniki,
  • Tomohisa Sujino,
  • Michiie Sakamoto,
  • Takanori Kanai,
  • Nobuhiro Nakamoto

DOI
https://doi.org/10.1038/s41467-021-24734-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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The cellular and molecular mechanisms underlying the resolution of non-alcoholic steatohepatitis remain incompletely understood. Here the authors report a single cell-based analysis that identified CD8 + tissue-resident memory T cells, which contribute to resolution of liver fibrosis potentially via elimination of hepatic stellate cells through Fas-mediated cytotoxicity.