Transformation of Amides to Thioamides Using an Efficient and Novel Thiating Reagent
Mohamed S. Gomaa,
Gaber El Enany,
Walid Fathalla,
Ibrahim A. I. Ali,
Samir. M. El Rayes
Affiliations
Mohamed S. Gomaa
Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia
Gaber El Enany
Department of Physics, College of Science and Arts in Uglat Asugour, Qassim University, Buraidah 52571, Saudi Arabia
Walid Fathalla
Scientific Department, Faculty of Engineering, Port Said University, Port Said 42526, Egypt
Ibrahim A. I. Ali
Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt
Samir. M. El Rayes
Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt
A convenient protocol was developed for the transformation of N-aryl-substituted benzamides to N-aryl-substituted benzothioamides using N-isopropyldithiocarbamate isopropyl ammonium salt as a novel thiating reagent. The major advantages of this protocol are its one-pot procedure, short reaction times, mild conditions, simple work-up, high yields and pure products.
